Penn State may be without several key players against Michigan on Saturday.
The Nittany Lions included four players as “game-time decisions” on their pregame availability report, which was released two hours prior to kickoff. That includes starting wide receiver Chase Sowell and starting defensive end Yvan Kemajou, along with defensive tackle Armstrong Nnodim and linebacker Cam Smith, who have played rotational roles when healthy.
The full availability reports for both teams are as follows:
| Team | Name | Position | Status |
| Penn State | Koby Howard | Wide receiver | Out |
| Penn State | LaVar Arrington II | Defensive end | Out |
| Penn State | Joshua Johnson | Cornerback | Out |
| Penn State | Max Granville | Defensive end | Out |
| Penn State | Alex Tatsch | Linebacker | Out |
| Penn State | Christian Askew | Cornerback | Out |
| Penn State | Tyler Armstead | Cornerback | Out |
| Penn State | Mason Robinson | Defensive end | Out |
| Penn State | Dayshaun Burnett | Defensive end | Out |
| Penn State | Will Tompkins | Offensive lineman | Out |
| Penn State | Cooper Alexander | Tight end | Out |
| Penn State | Cristiano Rosa | Kicker | Out |
| Penn State | Liam Andrews | Defensive tackle | Out |
| Penn State | Cam Smith | Linebacker | Game-time decision |
| Penn State | Yvan Kemajou | Defensive end | Game-time decision |
| Penn State | Chase Sowell | Wide receiver | Game-time decision |
| Penn State | Armstrong Nnodim | Defensive tackle | Game-time decision |
| Michigan | Braydon Alford | Wide receiver | Out |
| Michigan | Micah Ka’apana | Running back | Out |
| Michigan | Julius Holly | Defensive end | Out |
| Michigan | Ace Hamilton | Offensive lineman | Out |
| Michigan | Andrew Sprague | Offensive lineman | Out |
| Michigan | Kendrick Bell | Wide receiver | Out |
| Michigan | Zack Marshall | Tight end | Out |
| Michigan | Brady Norton | Offensive lineman | Out |
| Michigan | Jake Guarnera | Offensive lineman | Game-time decision |
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